4OCC
co-crystal structure of MDM2(17-111) in complex with compound 48
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C (A, C, E) | E3 ubiquitin-protein ligase Mdm2 | polymer | 96 | 11156.1 | 3 | UniProt (Q00987) Pfam (PF02201) | Homo sapiens (human) | Double minute 2 protein, Hdm2, Oncoprotein Mdm2, p53-binding protein Mdm2 |
| 2 | D, E, F (A, C, E) | [(2R,5R,6R)-4-[(2S)-1-(tert-butylsulfonyl)butan-2-yl]-6-(3-chlorophenyl)-5-(4-chlorophenyl)-3-oxomorpholin-2-yl]acetic acid | non-polymer | 556.5 | 3 | Chemie (2TZ) | |||
| 3 | G, H, I (A, C, E) | water | water | 18.0 | 324 | Chemie (HOH) |
Sequence modifications
A, C, E: 17 - 111 (UniProt: Q00987)
| PDB | External Database | Details |
|---|---|---|
| Gly 16 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 33468.2 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 1669.5 | |
| All* | Total formula weight | 35137.7 |
