4OAS

co-crystal structure of MDM2 (17-111) in complex with compound 25

Summary for 4OAS

• Entry DOI: 10.2210/pdb4oas/pdb
• Related: 4ERE 4ERF
• Descriptor: E3 ubiquitin-protein ligase Mdm2, [(3R,5R,6S)-1-[(2S)-1-(tert-butylsulfonyl)butan-2-yl]-5-(3-chlorophenyl)-6-(4-chlorophenyl)-3-methyl-2-oxopiperidin-3-yl]acetic acid, SULFATE ION, ... (4 entities in total)
• Functional Keywords: mdm2. 53, protein-protein interaction, inhibitor, ligase-ligase inhibitor complex, ligase/ligase inhibitor
• Biological source: Homo sapiens (human)
• Cellular location: Nucleus, nucleoplasm: Q00987
• Total number of polymer chains: 3
• Total formula weight: 35269.88

Authors

Huang, X. (deposition date: 2014-01-06, release date: 2014-02-19, Last modification date: 2024-02-28)

• Primary citation: Sun, D.,Li, Z.,Rew, Y.,Gribble, M.,Bartberger, M.D.,Beck, H.P.,Canon, J.,Chen, A.,Chen, X.,Chow, D.,Deignan, J.,Duquette, J.,Eksterowicz, J.,Fisher, B.,Fox, B.M.,Fu, J.,Gonzalez, A.Z.,Gonzalez-Lopez De Turiso, F.,Houze, J.B.,Huang, X.,Jiang, M.,Jin, L.,Kayser, F.,Liu, J.J.,Lo, M.C.,Long, A.M.,Lucas, B.,McGee, L.R.,McIntosh, J.,Mihalic, J.,Oliner, J.D.,Osgood, T.,Peterson, M.L.,Roveto, P.,Saiki, A.Y.,Shaffer, P.,Toteva, M.,Wang, Y.,Wang, Y.C.,Wortman, S.,Yakowec, P.,Yan, X.,Ye, Q.,Yu, D.,Yu, M.,Zhao, X.,Zhou, J.,Zhu, J.,Olson, S.H.,Medina, J.C.; Discovery of AMG 232, a Potent, Selective, and Orally Bioavailable MDM2-p53 Inhibitor in Clinical Development.; J.Med.Chem., 57:1454-1472, 2014; PubMed: 24456472; DOI: 10.1021/jm401753e

Experimental method

X-RAY DIFFRACTION (1.7 Å)