4OAS
co-crystal structure of MDM2 (17-111) in complex with compound 25
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005634 | cellular_component | nucleus |
| A | 0043066 | biological_process | negative regulation of apoptotic process |
| A | 0051726 | biological_process | regulation of cell cycle |
| C | 0005634 | cellular_component | nucleus |
| C | 0043066 | biological_process | negative regulation of apoptotic process |
| C | 0051726 | biological_process | regulation of cell cycle |
| E | 0005634 | cellular_component | nucleus |
| E | 0043066 | biological_process | negative regulation of apoptotic process |
| E | 0051726 | biological_process | regulation of cell cycle |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE 2SW A 201 |
| Chain | Residue |
| A | LEU54 |
| A | HOH321 |
| E | ARG97 |
| A | GLY58 |
| A | GLN59 |
| A | ILE61 |
| A | VAL93 |
| A | LYS94 |
| A | HIS96 |
| A | ILE99 |
| A | TYR100 |
| site_id | AC2 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE 2SW C 201 |
| Chain | Residue |
| A | ARG97 |
| C | LEU54 |
| C | GLY58 |
| C | GLN59 |
| C | ILE61 |
| C | VAL93 |
| C | LYS94 |
| C | HIS96 |
| C | ILE99 |
| C | HOH340 |
| C | HOH414 |
| site_id | AC3 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE 2SW E 201 |
| Chain | Residue |
| C | HOH377 |
| E | LEU54 |
| E | GLN59 |
| E | ILE61 |
| E | MET62 |
| E | VAL93 |
| E | LYS94 |
| E | HIS96 |
| E | TYR100 |
| site_id | AC4 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE SO4 E 202 |
| Chain | Residue |
| A | PRO20 |
| A | ALA21 |
| C | LYS51 |
| E | LYS51 |
| E | HOH317 |
| E | HOH321 |
| E | HOH342 |
