4OAS

co-crystal structure of MDM2 (17-111) in complex with compound 25

4OAS の概要

• エントリーDOI: 10.2210/pdb4oas/pdb
• 関連するPDBエントリー: 4ERE 4ERF
• 分子名称: E3 ubiquitin-protein ligase Mdm2, [(3R,5R,6S)-1-[(2S)-1-(tert-butylsulfonyl)butan-2-yl]-5-(3-chlorophenyl)-6-(4-chlorophenyl)-3-methyl-2-oxopiperidin-3-yl]acetic acid, SULFATE ION, ... (4 entities in total)
• 機能のキーワード: mdm2. 53, protein-protein interaction, inhibitor, ligase-ligase inhibitor complex, ligase/ligase inhibitor
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Nucleus, nucleoplasm: Q00987
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 35269.88

構造登録者

Huang, X. (登録日: 2014-01-06, 公開日: 2014-02-19, 最終更新日: 2024-02-28)

• 主引用文献: Sun, D.,Li, Z.,Rew, Y.,Gribble, M.,Bartberger, M.D.,Beck, H.P.,Canon, J.,Chen, A.,Chen, X.,Chow, D.,Deignan, J.,Duquette, J.,Eksterowicz, J.,Fisher, B.,Fox, B.M.,Fu, J.,Gonzalez, A.Z.,Gonzalez-Lopez De Turiso, F.,Houze, J.B.,Huang, X.,Jiang, M.,Jin, L.,Kayser, F.,Liu, J.J.,Lo, M.C.,Long, A.M.,Lucas, B.,McGee, L.R.,McIntosh, J.,Mihalic, J.,Oliner, J.D.,Osgood, T.,Peterson, M.L.,Roveto, P.,Saiki, A.Y.,Shaffer, P.,Toteva, M.,Wang, Y.,Wang, Y.C.,Wortman, S.,Yakowec, P.,Yan, X.,Ye, Q.,Yu, D.,Yu, M.,Zhao, X.,Zhou, J.,Zhu, J.,Olson, S.H.,Medina, J.C.; Discovery of AMG 232, a Potent, Selective, and Orally Bioavailable MDM2-p53 Inhibitor in Clinical Development.; J.Med.Chem., 57:1454-1472, 2014; PubMed: 24456472; DOI: 10.1021/jm401753e

実験手法

X-RAY DIFFRACTION (1.7 Å)