4OAK

Crystal structure of vancomycin resistance D,D-dipeptidase/D,D-pentapeptidase VanXYc D59S mutant in complex with D-Alanine-D-Alanine and copper (II)

4OAK の概要

• エントリーDOI: 10.2210/pdb4oak/pdb
• 関連するPDBエントリー: 4F78 4MUQ 4MUR 4MUS 4MUT
• 分子名称: D,D-dipeptidase/D,D-carboxypeptidase, COPPER (II) ION, D-ALANINE, ... (8 entities in total)
• 機能のキーワード: center for structural genomics of infectious diseases, csgid, national institute of allergy and infectious diseases, niaid, alpha+beta protein, metallopeptidase, hedgehog/dd-peptidase fold, merops m15b subfamily, zn2+-dependent, vancomycin resistance, antibiotic resistance, hydrolase
• 由来する生物種: Enterococcus gallinarum
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 53079.59

構造登録者

Stogios, P.J.,Evdokimova, E.,Meziane-Cherif, D.,Di Leo, R.,Yim, V.,Courvalin, P.,Savchenko, A.,Anderson, W.F.,Center for Structural Genomics of Infectious Diseases (CSGID) (登録日: 2014-01-04, 公開日: 2014-01-15, 最終更新日: 2023-09-20)

• 主引用文献: Meziane-Cherif, D.,Stogios, P.J.,Evdokimova, E.,Savchenko, A.,Courvalin, P.; Structural basis for the evolution of vancomycin resistance D,D-peptidases.; Proc.Natl.Acad.Sci.USA, 111:5872-5877, 2014; PubMed: 24711382; DOI: 10.1073/pnas.1402259111

実験手法

X-RAY DIFFRACTION (2 Å)