4O9R
Human Smoothened Receptor structure in complex with cyclopamine
Summary for 4O9R
Entry DOI | 10.2210/pdb4o9r/pdb |
Descriptor | Smoothened homolog/Soluble cytochrome b562 chimeric protein, Cyclopamine (2 entities in total) |
Functional Keywords | serial femtosecond crystallography, human smo receptor, cyclopamine, novel protein engineering, gpcr network, psi-biology, free electron laser, structural genomics, membrane protein, xfel, lcp, room temperature structure, gpcr, membrane, signaling protein |
Biological source | Homo sapiens More |
Cellular location | Membrane ; Multi-pass membrane protein : Q99835 |
Total number of polymer chains | 1 |
Total formula weight | 52806.82 |
Authors | Wang, C.,Weierstall, U.,James, D.,White, T.A.,Wang, D.,Liu, W.,Spence, J.C.H.,Doak, R.B.,Nelson, G.,Fromme, P.,Fromme, R.,Grotjohann, I.,Kupitz, C.,Zatsepin, N.A.,Liu, H.,Basu, S.,Wacker, D.,Han, G.W.,Katritch, V.,Boutet, S.,Messerschmidt, M.,Willams, G.J.,Koglin, J.E.,Seibert, M.M.,Klinker, M.,Gati, C.,Shoeman, R.L.,Barty, A.,Chapman, H.N.,Kirian, R.A.,Beyerlein, K.R.,Stevens, R.C.,Li, D.,Shah, S.T.A.,Howe, N.,Caffrey, M.,Cherezov, V.,GPCR Network (GPCR) (deposition date: 2014-01-02, release date: 2014-03-05, Last modification date: 2023-09-20) |
Primary citation | Weierstall, U.,James, D.,Wang, C.,White, T.A.,Wang, D.,Liu, W.,Spence, J.C.,Bruce Doak, R.,Nelson, G.,Fromme, P.,Fromme, R.,Grotjohann, I.,Kupitz, C.,Zatsepin, N.A.,Liu, H.,Basu, S.,Wacker, D.,Han, G.W.,Katritch, V.,Boutet, S.,Messerschmidt, M.,Williams, G.J.,Koglin, J.E.,Marvin Seibert, M.,Klinker, M.,Gati, C.,Shoeman, R.L.,Barty, A.,Chapman, H.N.,Kirian, R.A.,Beyerlein, K.R.,Stevens, R.C.,Li, D.,Shah, S.T.,Howe, N.,Caffrey, M.,Cherezov, V. Lipidic cubic phase injector facilitates membrane protein serial femtosecond crystallography. Nat Commun, 5:3309-3309, 2014 Cited by PubMed: 24525480DOI: 10.1038/ncomms4309 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.204 Å) |
Structure validation
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