4O9R
Human Smoothened Receptor structure in complex with cyclopamine
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Smoothened homolog/Soluble cytochrome b562 chimeric protein | polymer | 468 | 52395.2 | 1 | UniProt (Q99835) UniProt (P0ABE7) Pfam (PF01534) | Homo sapiens | |
| 2 | B (A) | Cyclopamine | non-polymer | 411.6 | 1 | Chemie (CY8) PubChem (16760050) PubChem (16760382) PubChem (176519873) PubChem (23651259) PubChem (23919695) PubChem (37818581) PubChem (37818584) PubChem (20518) PubChem (44593473) PubChem (46783360) PubChem (40619433) PubChem (44118238) PubChem (58682623) PubChem (58885171) PubChem (66577043) PubChem (67477143) PubChem (73440807) PubChem (57519537) PubChem (58185650) PubChem (58885159) PubChem (143567069) PubChem (4113848) PubChem (442972) PubChem (86287406) PubChem (91654170) PubChem (92311543) PubChem (92311439) PubChem (5316548) PubChem (124835765) PubChem (92311443) PubChem (92311544) PubChem (126660112) PubChem (6325009) PubChem (102004827) PubChem (134694700) PubChem (117758465) PubChem (118983942) PubChem (121271016) PubChem (122130428) PubChem (9844520) PubChem (124835762) PubChem (124835763) PubChem (124835764) PubChem (126660312) PubChem (129375254) PubChem (129606911) PubChem (131700441) PubChem (133687897) PubChem (134336480) PubChem (134852210) PubChem (137704777) PubChem (138756127) PubChem (144152952) PubChem (155196952) PubChem (160363420) PubChem (163101895) PubChem (163101896) PubChem (163284919) PubChem (163889965) PubChem (172897585) |
Sequence modifications
A: 190 - 433 (UniProt: Q99835)
A: 1001 - 1106 (UniProt: P0ABE7)
A: 441 - 555 (UniProt: Q99835)
| PDB | External Database | Details |
|---|---|---|
| Gly 187 | - | expression tag |
| Gly 188 | - | expression tag |
| Thr 189 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Trp 1007 | Met 29 | engineered mutation |
| Ile 1102 | His 124 | engineered mutation |
| Leu 1106 | Arg 128 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 52395.2 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 411.6 | |
| All* | Total formula weight | 52806.8 |
