4O9R
Human Smoothened Receptor structure in complex with cyclopamine
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Smoothened homolog/Soluble cytochrome b562 chimeric protein | polymer | 468 | 52395.2 | 1 | UniProt (Q99835) UniProt (P0ABE7) Pfam (PF01534) Pfam (PF07361) | Homo sapiens | |
| 2 | B (A) | Cyclopamine | non-polymer | 411.6 | 1 | Chemie (CY8) |
Sequence modifications
A: 190 - 433 (UniProt: Q99835)
A: 1001 - 1106 (UniProt: P0ABE7)
A: 441 - 555 (UniProt: Q99835)
| PDB | External Database | Details |
|---|---|---|
| Gly 187 | - | expression tag |
| Gly 188 | - | expression tag |
| Thr 189 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Trp 1007 | Met 29 | engineered mutation |
| Ile 1102 | His 124 | engineered mutation |
| Leu 1106 | Arg 128 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 52395.2 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 411.6 | |
| All* | Total formula weight | 52806.8 |
