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4O8F

Crystal Structure of the complex between PPARgamma mutant R357A and rosiglitazone

Summary for 4O8F
Entry DOI10.2210/pdb4o8f/pdb
Related2PRG 3B3K 4L96 4L98
DescriptorPeroxisome proliferator-activated receptor gamma, 2,4-THIAZOLIDIINEDIONE, 5-[[4-[2-(METHYL-2-PYRIDINYLAMINO)ETHOXY]PHENYL]METHYL]-(9CL) (3 entities in total)
Functional Keywordsbundle of alpha-helices, small four-stranded beta-sheet, transcription factor, rxralpha, transcription-transcription inhibitor complex, transcription/transcription inhibitor
Biological sourceHomo sapiens (human)
Total number of polymer chains2
Total formula weight65930.27
Authors
Pochetti, G.,Montanari, R.,Capelli, D.,Chiaraluce, R.,Consalvi, V.,Lori, C.,Loiodice, F.,Laghezza, A.,Pasquo, A.,Cervoni, L.,Aschi, M. (deposition date: 2013-12-27, release date: 2014-07-23, Last modification date: 2023-09-20)
Primary citationLori, C.,Pasquo, A.,Montanari, R.,Capelli, D.,Consalvi, V.,Chiaraluce, R.,Cervoni, L.,Loiodice, F.,Laghezza, A.,Aschi, M.,Giorgi, A.,Pochetti, G.
Structural basis of the transactivation deficiency of the human PPAR gamma F360L mutant associated with familial partial lipodystrophy.
Acta Crystallogr.,Sect.D, 70:1965-1976, 2014
Cited by
PubMed: 25004973
DOI: 10.1107/S1399004714009638
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.6 Å)
Structure validation

217705

数据于2024-03-27公开中

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