4O8F

Crystal Structure of the complex between PPARgamma mutant R357A and rosiglitazone

4O8F の概要

• エントリーDOI: 10.2210/pdb4o8f/pdb
• 関連するPDBエントリー: 2PRG 3B3K 4L96 4L98
• 分子名称: Peroxisome proliferator-activated receptor gamma, 2,4-THIAZOLIDIINEDIONE, 5-[[4-[2-(METHYL-2-PYRIDINYLAMINO)ETHOXY]PHENYL]METHYL]-(9CL) (3 entities in total)
• 機能のキーワード: bundle of alpha-helices, small four-stranded beta-sheet, transcription factor, rxralpha, transcription-transcription inhibitor complex, transcription/transcription inhibitor
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 65930.27

構造登録者

Pochetti, G.,Montanari, R.,Capelli, D.,Chiaraluce, R.,Consalvi, V.,Lori, C.,Loiodice, F.,Laghezza, A.,Pasquo, A.,Cervoni, L.,Aschi, M. (登録日: 2013-12-27, 公開日: 2014-07-23, 最終更新日: 2023-09-20)

• 主引用文献: Lori, C.,Pasquo, A.,Montanari, R.,Capelli, D.,Consalvi, V.,Chiaraluce, R.,Cervoni, L.,Loiodice, F.,Laghezza, A.,Aschi, M.,Giorgi, A.,Pochetti, G.; Structural basis of the transactivation deficiency of the human PPAR gamma F360L mutant associated with familial partial lipodystrophy.; Acta Crystallogr.,Sect.D, 70:1965-1976, 2014; PubMed: 25004973; DOI: 10.1107/S1399004714009638

実験手法

X-RAY DIFFRACTION (2.6 Å)