4O6L
Crystal Structure of TTK kinase domain with an inhibitor: 401498 (N-[(1R)-1-(2-chlorophenyl)propyl]-3-{4-[(1-methylpiperidin-4-yl)oxy]phenyl}-1H-indazole-5-carboxamide)
Summary for 4O6L
Entry DOI | 10.2210/pdb4o6l/pdb |
Descriptor | Dual specificity protein kinase TTK, N-[(1R)-1-(2-chlorophenyl)propyl]-3-{4-[(1-methylpiperidin-4-yl)oxy]phenyl}-1H-indazole-5-carboxamide, GLYCEROL, ... (4 entities in total) |
Functional Keywords | kinase, ttk, inhibitor, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 2 |
Total formula weight | 66588.73 |
Authors | Qiu, W.,Plotnikova, O.,Feher, M.,Awrey, D.E.,Chirgadze, N.Y. (deposition date: 2013-12-22, release date: 2014-12-24) |
Primary citation | Qiu, W.,Plotnikova, O.,Feher, M.,Awrey, D.E.,Chirgadze, N.Y. Crystal Structure of TTK kinase domain with an inhibitor: 401498 TO BE PUBLISHED, |
Experimental method | X-RAY DIFFRACTION (2.38 Å) |
Structure validation
Download full validation report