4O6L

Crystal Structure of TTK kinase domain with an inhibitor: 401498 (N-[(1R)-1-(2-chlorophenyl)propyl]-3-{4-[(1-methylpiperidin-4-yl)oxy]phenyl}-1H-indazole-5-carboxamide)

Summary for 4O6L

• Entry DOI: 10.2210/pdb4o6l/pdb
• Descriptor: Dual specificity protein kinase TTK, N-[(1R)-1-(2-chlorophenyl)propyl]-3-{4-[(1-methylpiperidin-4-yl)oxy]phenyl}-1H-indazole-5-carboxamide, GLYCEROL, ... (4 entities in total)
• Functional Keywords: kinase, ttk, inhibitor, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 66588.73

Authors

Qiu, W.,Plotnikova, O.,Feher, M.,Awrey, D.E.,Chirgadze, N.Y. (deposition date: 2013-12-22, release date: 2014-12-24)

• Primary citation: Qiu, W.,Plotnikova, O.,Feher, M.,Awrey, D.E.,Chirgadze, N.Y.; Crystal Structure of TTK kinase domain with an inhibitor: 401498; TO BE PUBLISHED,

Experimental method

X-RAY DIFFRACTION (2.38 Å)