4O67
Human cyclic GMP-AMP synthase (cGAS) in complex with GAMP
Summary for 4O67
Entry DOI | 10.2210/pdb4o67/pdb |
Related | 4O68 4O69 4O6A |
Descriptor | Cyclic GMP-AMP synthase, cGAMP, ZINC ION, ... (4 entities in total) |
Functional Keywords | immune response, transferase |
Biological source | Homo sapiens |
Cellular location | Cytoplasm, cytosol : Q8N884 |
Total number of polymer chains | 2 |
Total formula weight | 86551.84 |
Authors | Zhang, X.,Chen, Z.,Zhang, X.W.,Chen, Z.J. (deposition date: 2013-12-20, release date: 2014-02-05, Last modification date: 2024-02-28) |
Primary citation | Zhang, X.,Wu, J.,Du, F.,Xu, H.,Sun, L.,Chen, Z.,Brautigam, C.A.,Zhang, X.,Chen, Z.J. The Cytosolic DNA Sensor cGAS Forms an Oligomeric Complex with DNA and Undergoes Switch-like Conformational Changes in the Activation Loop. Cell Rep, 6:421-430, 2014 Cited by PubMed: 24462292DOI: 10.1016/j.celrep.2014.01.003 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.444 Å) |
Structure validation
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