4O4X
Crystal structure of the vaccine antigen Transferrin Binding Protein B (TbpB) double mutant Tyr-167-Ala and Trp-176-Ala from Haemophilus parasuis Hp5
Summary for 4O4X
Entry DOI | 10.2210/pdb4o4x/pdb |
Related | 4O3W 4O3X 4O3Y 4O3Z 4O49 4O4U |
Descriptor | TbpB, GLYCEROL, SULFATE ION, ... (5 entities in total) |
Functional Keywords | structure-based vaccine design, transferrin receptor, iron acquisition, host pathogen interaction, surface lipoprotein, metal transport |
Biological source | Haemophilus parasuis |
Total number of polymer chains | 2 |
Total formula weight | 118403.65 |
Authors | Calmettes, C.,Yu, R.H.,Schryvers, A.B.,Moraes, T.F. (deposition date: 2013-12-19, release date: 2015-01-14, Last modification date: 2015-03-04) |
Primary citation | Frandoloso, R.,Martinez-Martinez, S.,Calmettes, C.,Fegan, J.,Costa, E.,Curran, D.,Yu, R.H.,Gutierrez-Martin, C.B.,Rodriguez-Ferri, E.F.,Moraes, T.F.,Schryvers, A.B. Nonbinding site-directed mutants of transferrin binding protein B exhibit enhanced immunogenicity and protective capabilities. Infect.Immun., 83:1030-1038, 2015 Cited by PubMed: 25547790DOI: 10.1128/IAI.02572-14 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.9 Å) |
Structure validation
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