4O3U

Zymogen HGF-beta/MET with Zymogen Activator Peptide ZAP2.3

Summary for 4O3U

Entry DOI	10.2210/pdb4o3u/pdb
Descriptor	Hepatocyte growth factor, Hepatocyte growth factor receptor, ZAP 2.3 (3 entities in total)
Functional Keywords	trypsin homoloy, receptor activation, transferase-growth factor complex, transferase/growth factor
Biological source	Homo sapiens (human) More
Cellular location	Membrane; Single-pass type I membrane protein. Isoform 3: Secreted: P14210
Total number of polymer chains	3
Total formula weight	91301.14
Authors	Eigenbrot, C.,Landgraf, K.E.,Steffek, M. (deposition date: 2013-12-18, release date: 2014-06-04, Last modification date: 2023-09-20)
Primary citation	Landgraf, K.E.,Steffek, M.,Quan, C.,Tom, J.,Yu, C.,Santell, L.,Maun, H.R.,Eigenbrot, C.,Lazarus, R.A. An allosteric switch for pro-HGF/Met signaling using zymogen activator peptides. Nat.Chem.Biol., 10:567-573, 2014 Cited by PubMed: 24859116 DOI: 10.1038/nchembio.1533 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.04 Å)

Structure validation