4O1O

Crystal Structure of RNase L in complex with 2-5A

Summary for 4O1O

• Entry DOI: 10.2210/pdb4o1o/pdb
• Related: 4O1P
• Descriptor: Ribonuclease L, [[(2R,3R,4R,5R)-5-(6-aminopurin-9-yl)-4-[[(2R,3R,4R,5R)-5-(6-aminopurin-9-yl)-4-[[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxy-oxolan-2-yl]methoxy-hydroxy-phosphoryl]oxy-3-hydroxy-oxolan-2-yl]methoxy-hydroxy-phosphoryl]oxy-3-hydroxy-oxolan-2-yl]methoxy-hydroxy-phosphoryl] phosphono hydrogen phosphate (2 entities in total)
• Functional Keywords: ankyrin repeat-kinase-rnase, 2-5a, transferase, hydrolase
• Biological source: Sus scrofa (pigs,swine,wild boar)
• Total number of polymer chains: 4
• Total formula weight: 329973.72

Authors

Huang, H.,Zeqiraj, E.,Ceccarelli, D.F.,Sicheri, F. (deposition date: 2013-12-16, release date: 2014-02-05, Last modification date: 2023-09-20)

• Primary citation: Huang, H.,Zeqiraj, E.,Dong, B.,Jha, B.K.,Duffy, N.M.,Orlicky, S.,Thevakumaran, N.,Talukdar, M.,Pillon, M.C.,Ceccarelli, D.F.,Wan, L.C.,Juang, Y.C.,Mao, D.Y.,Gaughan, C.,Brinton, M.A.,Perelygin, A.A.,Kourinov, I.,Guarne, A.,Silverman, R.H.,Sicheri, F.; Dimeric structure of pseudokinase RNase L bound to 2-5A reveals a basis for interferon-induced antiviral activity.; Mol.Cell, 53:221-234, 2014; PubMed: 24462203; DOI: 10.1016/j.molcel.2013.12.025

Experimental method

X-RAY DIFFRACTION (3.27 Å)