4O1M

Toxoplasma gondii Enoyl acyl carrier protein reductase

Summary for 4O1M

• Entry DOI: 10.2210/pdb4o1m/pdb
• Related: 2O2S 2O2Y 2O50 2PTG 3NJ8
• Descriptor: Enoyl-acyl carrier reductase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE (3 entities in total)
• Functional Keywords: rossmann fold, oxidoreductase, enoyl acyl carrier protein reductase
• Biological source: Toxoplasma gondii
• Total number of polymer chains: 6
• Total formula weight: 204329.88

Authors

Muench, S.P.,Wilkinson, C.,Prigge, S.T.,Rice, D.W. (deposition date: 2013-12-16, release date: 2014-02-05, Last modification date: 2024-04-03)

• Primary citation: Wilkinson, C.,Mcphillie, M.J.,Zhou, Y.,Woods, S.,Afanador, G.A.,Rawson, S.,Khaliq, F.,Prigge, S.T.,Roberts, C.W.,Rice, D.W.,Mcleod, R.,Fishwick, C.W.,Muench, S.P.; The benzimidazole based drugs show good activity against T. gondii but poor activity against its proposed enoyl reductase enzyme target; Bioorg.Med.Chem.Lett., 24:911-916, 2014; PubMed: 24398298; DOI: 10.1016/j.bmcl.2013.12.066

Experimental method

X-RAY DIFFRACTION (2 Å)