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3NJ8

Crystal structure of T. gondii enoyl acyl carrier protein reductase with bound triclosan like inhibitor

Summary for 3NJ8
Entry DOI10.2210/pdb3nj8/pdb
Related2O2S 2O2Y 2O50
DescriptorEnoyl-acyl carrier reductase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, 3-chloro-4-(2-hydroxy-4-propylphenoxy)benzonitrile, ... (4 entities in total)
Functional Keywordsenoyl reductase, enr triclosan, rossmann nad binding fold, nadh binding, oxidoreductase
Biological sourceToxoplasma gondii
Total number of polymer chains2
Total formula weight68685.44
Authors
Muench, S.P.,Ruzheinikov, S.N.,Rice, D.W. (deposition date: 2010-06-17, release date: 2010-09-29, Last modification date: 2024-02-21)
Primary citationTipparaju, S.K.,Muench, S.P.,Mui, E.J.,Ruzheinikov, S.N.,Lu, J.Z.,Hutson, S.L.,Kirisits, M.J.,Prigge, S.T.,Roberts, C.W.,Henriquez, F.L.,Kozikowski, A.P.,Rice, D.W.,McLeod, R.L.
Identification and development of novel inhibitors of Toxoplasma gondii enoyl reductase.
J.Med.Chem., 53:6287-6300, 2010
Cited by
PubMed: 20698542
DOI: 10.1021/jm9017724
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.7 Å)
Structure validation

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