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4NZO

Crystal structure of the catalytic domain of PPIP5K2 in complex with AMPPNP and 2,5-DI-O-BN-INSP4

4NZO の概要
エントリーDOI10.2210/pdb4nzo/pdb
関連するPDBエントリー3T9B 4NZM 4NZN
分子名称Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, (1R,2R,3r,4S,5S,6s)-3,6-bis(benzyloxy)cyclohexane-1,2,4,5-tetrayl tetrakis[dihydrogen (phosphate)], ... (5 entities in total)
機能のキーワードatp-grasp fold, inositol pyrophosphate kinase, kinase, drug discovery, enzymology, inositol pyrophosphates, transferase-transferase inhibitor complex, transferase/transferase inhibitor
由来する生物種Homo sapiens (human)
細胞内の位置Cytoplasm, cytosol: O43314
タンパク質・核酸の鎖数1
化学式量合計38828.32
構造登録者
Wang, H.,Shears, S.B. (登録日: 2013-12-12, 公開日: 2014-04-02, 最終更新日: 2023-09-20)
主引用文献Wang, H.,Godage, H.Y.,Riley, A.M.,Weaver, J.D.,Shears, S.B.,Potter, B.V.
Synthetic Inositol Phosphate Analogs Reveal that PPIP5K2 Has a Surface-Mounted Substrate Capture Site that Is a Target for Drug Discovery.
Chem.Biol., 21:689-699, 2014
Cited by
PubMed: 24768307
DOI: 10.1016/j.chembiol.2014.03.009
主引用文献が同じPDBエントリー
実験手法
X-RAY DIFFRACTION (1.9 Å)
構造検証レポート
Validation report summary of 4nzo
検証レポート(詳細版)ダウンロードをダウンロード

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件を2024-06-19に公開中

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