4NZO
Crystal structure of the catalytic domain of PPIP5K2 in complex with AMPPNP and 2,5-DI-O-BN-INSP4
4NZO の概要
エントリーDOI | 10.2210/pdb4nzo/pdb |
関連するPDBエントリー | 3T9B 4NZM 4NZN |
分子名称 | Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, (1R,2R,3r,4S,5S,6s)-3,6-bis(benzyloxy)cyclohexane-1,2,4,5-tetrayl tetrakis[dihydrogen (phosphate)], ... (5 entities in total) |
機能のキーワード | atp-grasp fold, inositol pyrophosphate kinase, kinase, drug discovery, enzymology, inositol pyrophosphates, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
由来する生物種 | Homo sapiens (human) |
細胞内の位置 | Cytoplasm, cytosol: O43314 |
タンパク質・核酸の鎖数 | 1 |
化学式量合計 | 38828.32 |
構造登録者 | |
主引用文献 | Wang, H.,Godage, H.Y.,Riley, A.M.,Weaver, J.D.,Shears, S.B.,Potter, B.V. Synthetic Inositol Phosphate Analogs Reveal that PPIP5K2 Has a Surface-Mounted Substrate Capture Site that Is a Target for Drug Discovery. Chem.Biol., 21:689-699, 2014 Cited by PubMed: 24768307DOI: 10.1016/j.chembiol.2014.03.009 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (1.9 Å) |
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