4NZO

Crystal structure of the catalytic domain of PPIP5K2 in complex with AMPPNP and 2,5-DI-O-BN-INSP4

Summary for 4NZO

Entry DOI	10.2210/pdb4nzo/pdb
Related	3T9B 4NZM 4NZN
Descriptor	Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, (1R,2R,3r,4S,5S,6s)-3,6-bis(benzyloxy)cyclohexane-1,2,4,5-tetrayl tetrakis[dihydrogen (phosphate)], ... (5 entities in total)
Functional Keywords	atp-grasp fold, inositol pyrophosphate kinase, kinase, drug discovery, enzymology, inositol pyrophosphates, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm, cytosol: O43314
Total number of polymer chains	1
Total formula weight	38828.32
Authors	Wang, H.,Shears, S.B. (deposition date: 2013-12-12, release date: 2014-04-02, Last modification date: 2023-09-20)
Primary citation	Wang, H.,Godage, H.Y.,Riley, A.M.,Weaver, J.D.,Shears, S.B.,Potter, B.V. Synthetic Inositol Phosphate Analogs Reveal that PPIP5K2 Has a Surface-Mounted Substrate Capture Site that Is a Target for Drug Discovery. Chem.Biol., 21:689-699, 2014 Cited by PubMed: 24768307 DOI: 10.1016/j.chembiol.2014.03.009 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.9 Å)

Structure validation