4NZM
Crystal structure of the catalytic domain of PPIP5K2 in complex with AMPPNP and 5-PA-InsP5
Summary for 4NZM
Entry DOI | 10.2210/pdb4nzm/pdb |
Related | 3T9B 4NZM 4NZN 4NZO |
Descriptor | Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, (2-oxo-2-{[(1s,2R,3S,4s,5R,6S)-2,3,4,5,6-pentakis(phosphonooxy)cyclohexyl]oxy}ethyl)phosphonic acid, ... (5 entities in total) |
Functional Keywords | atp-grasp fold, inositol pyrophosphate kinase, drug discovery, kinase, enzymology, inositol pyrophosphates, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm, cytosol: O43314 |
Total number of polymer chains | 1 |
Total formula weight | 38874.38 |
Authors | Wang, H.,Shears, S.B. (deposition date: 2013-12-12, release date: 2014-04-02, Last modification date: 2023-09-20) |
Primary citation | Wang, H.,Godage, H.Y.,Riley, A.M.,Weaver, J.D.,Shears, S.B.,Potter, B.V. Synthetic Inositol Phosphate Analogs Reveal that PPIP5K2 Has a Surface-Mounted Substrate Capture Site that Is a Target for Drug Discovery. Chem.Biol., 21:689-699, 2014 Cited by PubMed: 24768307DOI: 10.1016/j.chembiol.2014.03.009 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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