4NZN
Crystal structure of the catalytic domain of PPIP5K2 in complex with AMPPNP and 2-O-BN-5-PA-INSP4
Summary for 4NZN
Entry DOI | 10.2210/pdb4nzn/pdb |
Related | 3T9B 4NZM 4NZO |
Descriptor | Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, (2-{[(1s,2R,3R,4r,5S,6S)-4-(benzyloxy)-2,3,5,6-tetrakis(phosphonooxy)cyclohexyl]oxy}-2-oxoethyl)phosphonic acid, ... (5 entities in total) |
Functional Keywords | atp-grasp fold, inositol pyrophosphate kinase, drug discovery, kinase, enzymology, inositol pyrophosphates, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm, cytosol: O43314 |
Total number of polymer chains | 1 |
Total formula weight | 38860.22 |
Authors | Wang, H.,Shears, S.B. (deposition date: 2013-12-12, release date: 2014-04-02, Last modification date: 2023-09-20) |
Primary citation | Wang, H.,Godage, H.Y.,Riley, A.M.,Weaver, J.D.,Shears, S.B.,Potter, B.V. Synthetic Inositol Phosphate Analogs Reveal that PPIP5K2 Has a Surface-Mounted Substrate Capture Site that Is a Target for Drug Discovery. Chem.Biol., 21:689-699, 2014 Cited by PubMed: 24768307DOI: 10.1016/j.chembiol.2014.03.009 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.75 Å) |
Structure validation
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