4NZ0

The EMCV 3Dpol structure at 2.8A resolution

4NZ0 の概要

• エントリーDOI: 10.2210/pdb4nz0/pdb
• 関連するPDBエントリー: 1U09 4nyz
• 分子名称: Genome polyprotein, GLYCEROL, CHLORIDE ION, ... (4 entities in total)
• 機能のキーワード: encephalomyocarditis virus, close right hand, rna dependent rna polymerase, transferase
• 由来する生物種: Mengo virus
• 細胞内の位置: Protein 2A: Host nucleus . Protein VP2: Virion. Protein VP3: Virion. Protein VP1: Virion. Protein 2B: Host cytoplasmic vesicle membrane ; Peripheral membrane protein ; Cytoplasmic side . Protein 2C: Host cytoplasmic vesicle membrane ; Peripheral membrane protein ; Cytoplasmic side . Protein 3A: Host cytoplasmic vesicle membrane ; Peripheral membrane protein ; Cytoplasmic side . Protein 3B: Virion . Protease 3C: Host cytoplasm . RNA-directed RNA polymerase 3D-POL: Host cytoplasmic vesicle membrane ; Peripheral membrane protein ; Cytoplasmic side : P12296
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 314239.23

構造登録者

Vives-adrian, L.,Ferrer-orta, C.,Verdaguer, N. (登録日: 2013-12-11, 公開日: 2014-03-19, 最終更新日: 2023-11-08)

• 主引用文献: Vives-Adrian, L.,Lujan, C.,Oliva, B.,van der Linden, L.,Selisko, B.,Coutard, B.,Canard, B.,van Kuppeveld, F.J.,Ferrer-Orta, C.,Verdaguer, N.; The crystal structure of a cardiovirus RNA-dependent RNA polymerase reveals an unusual conformation of the polymerase active site; J.Virol., 88:5595-5607, 2014; PubMed: 24600002; DOI: 10.1128/JVI.03502-13

実験手法

X-RAY DIFFRACTION (2.8 Å)