4NXR

Crystal Structure of T-cell Lymphoma Invasion and Metastasis-1 PDZ Domain Quadruple Mutant (QM) in Complex With Neurexin-1 Peptide

4NXR の概要

• エントリーDOI: 10.2210/pdb4nxr/pdb
• 関連するPDBエントリー: 3KZD 3KZE 4GVC 4GVD 4NXP 4NXQ
• 分子名称: T-lymphoma invasion and metastasis-inducing protein 1, Neurexin-2-beta Peptide, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ... (5 entities in total)
• 機能のキーワード: beta barrel fold protein, pdz domain, peptide binding, specificity mutant, scaffold signaling protein for cell adhesion and cell junction, signaling domain, signaling protein-peptide complex, signaling protein/peptide
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Cell junction: Q13009; Membrane ; Single-pass type I membrane protein : P58401
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 11742.17

構造登録者

Liu, X.,Speckhard, D.C.,Shepherd, T.R.,Hengel, S.R.,Fuentes, E.J. (登録日: 2013-12-09, 公開日: 2015-05-13, 最終更新日: 2023-09-20)

• 主引用文献: Liu, X.,Speckhard, D.C.,Shepherd, T.R.,Sun, Y.J.,Hengel, S.R.,Yu, L.,Fowler, C.A.,Gakhar, L.,Fuentes, E.J.; Distinct Roles for Conformational Dynamics in Protein-Ligand Interactions.; Structure, 24:2053-2066, 2016; PubMed: 27998539; DOI: 10.1016/j.str.2016.08.019

実験手法

X-RAY DIFFRACTION (1.9 Å)