4NWU

Crystal structure of APE1551, an anti-human NGF Fab with a nine amino acid insertion in CDR H1

Summary for 4NWU

• Entry DOI: 10.2210/pdb4nwu/pdb
• Descriptor: APE1551 Ab Fab heavy chain, APE1551 Ab Fab light chain (3 entities in total)
• Functional Keywords: beta-sandwich, human beta nerve growth factor, immune system
• Biological source: Homo sapiens (human); More
• Cellular location: Secreted : P01857
• Total number of polymer chains: 2
• Total formula weight: 50308.71

Authors

Verdino, P.,Stanfield, R.L.,Wilson, I.A. (deposition date: 2013-12-06, release date: 2014-10-22, Last modification date: 2024-04-03)

• Primary citation: Bowers, P.M.,Verdino, P.,Wang, Z.,da Silva Correia, J.,Chhoa, M.,Macondray, G.,Do, M.,Neben, T.Y.,Horlick, R.A.,Stanfield, R.L.,Wilson, I.A.,King, D.J.; Nucleotide insertions and deletions complement point mutations to massively expand the diversity created by somatic hypermutation of antibodies.; J.Biol.Chem., 289:33557-33567, 2014; PubMed: 25320089; DOI: 10.1074/jbc.M114.607176

Experimental method

X-RAY DIFFRACTION (1.602 Å)