4NWG

Crystal structure of the tyrosine phosphatase SHP-2 with E139D mutation

Summary for 4NWG

• Entry DOI: 10.2210/pdb4nwg/pdb
• Related: 4NWF 4NXD
• Descriptor: Tyrosine-protein phosphatase non-receptor type 11, 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, ... (5 entities in total)
• Functional Keywords: hydrolase
• Biological source: Homo sapiens (human)
• Cellular location: Cytoplasm: Q06124
• Total number of polymer chains: 2
• Total formula weight: 124872.85

Authors

Qiu, W.,Lin, A.,Hutchinson, A.,Romanov, V.,Ruzanov, M.,Thompson, C.,Lam, K.,Kisselman, G.,Battalie, K.,Chirgadze, N.Y. (deposition date: 2013-12-06, release date: 2014-12-10, Last modification date: 2024-02-28)

• Primary citation: Qiu, W.,Lin, A.,Hutchinson, A.,Romanov, V.,Ruzanov, M.,Thompson, C.,Lam, K.,Kisselman, G.,Battalie, K.,Chirgadze, N.Y.; Crystal structure of the tyrosine phosphatase SHP-2 with E139D mutation; To be Published,

Experimental method

X-RAY DIFFRACTION (2.45 Å)