4NWG
Crystal structure of the tyrosine phosphatase SHP-2 with E139D mutation
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Tyrosine-protein phosphatase non-receptor type 11 | polymer | 539 | 61994.0 | 2 | UniProt (Q06124) Pfam (PF00017) Pfam (PF00102) | Homo sapiens (human) | Protein-tyrosine phosphatase 1D, PTP-1D, Protein-tyrosine phosphatase 2C, PTP-2C, SH-PTP2, SHP-2, Shp2, SH-PTP3 |
| 2 | C, D, E, F, G... (A, B) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 11 | Chemie (EDO) | |||
| 3 | J (A) | DI(HYDROXYETHYL)ETHER | non-polymer | 106.1 | 1 | Chemie (PEG) | |||
| 4 | K (B) | SULFATE ION | non-polymer | 96.1 | 1 | Chemie (SO4) | |||
| 5 | P, Q (A, B) | water | water | 18.0 | 362 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 539 (UniProt: Q06124)
| PDB | External Database | Details |
|---|---|---|
| Asp 139 | Glu 139 | engineered mutation |
| - | Gln 408 | deletion |
| - | Ala 409 | deletion |
| - | Leu 410 | deletion |
| - | Leu 411 | deletion |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 123987.9 | |
| Non-Polymers* | Number of molecules | 13 |
| Total formula weight | 884.9 | |
| All* | Total formula weight | 124872.8 |
