4NVP

Structure of the cyclic nucleotide-binding domain of HCN4 channel complexed with 7-CH-cAMP

Summary for 4NVP

• Entry DOI: 10.2210/pdb4nvp/pdb
• Related: 3OTF 3U11
• Descriptor: Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4, (2S,4aR,6R,7R,7aS)-6-(4-amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)tetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinine-2,7-diol 2-oxide (3 entities in total)
• Functional Keywords: cyclic nucleotide binding domain, potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel, cytoplasmic domain, transport protein
• Biological source: Homo sapiens (human)
• Cellular location: Cell membrane; Multi-pass membrane protein: Q9Y3Q4
• Total number of polymer chains: 1
• Total formula weight: 24826.22

Authors

Alfieri, A.,Moroni, A. (deposition date: 2013-12-05, release date: 2014-03-19, Last modification date: 2024-04-03)

• Primary citation: Moller, S.,Alfieri, A.,Bertinetti, D.,Aquila, M.,Schwede, F.,Lolicato, M.,Rehmann, H.,Moroni, A.,Herberg, F.W.; Cyclic Nucleotide Mapping of Hyperpolarization-Activated Cyclic Nucleotide-Gated (HCN) Channels.; Acs Chem.Biol., 9:1128-1137, 2014; PubMed: 24605759; DOI: 10.1021/cb400904s

Experimental method

X-RAY DIFFRACTION (2.5 Å)