4NVP

Structure of the cyclic nucleotide-binding domain of HCN4 channel complexed with 7-CH-cAMP

4NVP の概要

• エントリーDOI: 10.2210/pdb4nvp/pdb
• 関連するPDBエントリー: 3OTF 3U11
• 分子名称: Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4, (2S,4aR,6R,7R,7aS)-6-(4-amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)tetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinine-2,7-diol 2-oxide (3 entities in total)
• 機能のキーワード: cyclic nucleotide binding domain, potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel, cytoplasmic domain, transport protein
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cell membrane; Multi-pass membrane protein: Q9Y3Q4
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 24826.22

構造登録者

Alfieri, A.,Moroni, A. (登録日: 2013-12-05, 公開日: 2014-03-19, 最終更新日: 2024-04-03)

• 主引用文献: Moller, S.,Alfieri, A.,Bertinetti, D.,Aquila, M.,Schwede, F.,Lolicato, M.,Rehmann, H.,Moroni, A.,Herberg, F.W.; Cyclic Nucleotide Mapping of Hyperpolarization-Activated Cyclic Nucleotide-Gated (HCN) Channels.; Acs Chem.Biol., 9:1128-1137, 2014; PubMed: 24605759; DOI: 10.1021/cb400904s

実験手法

X-RAY DIFFRACTION (2.5 Å)