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4NUS

Rsk2 N-terminal kinase in complex with LJH685

Summary for 4NUS
Entry DOI10.2210/pdb4nus/pdb
DescriptorRibosomal protein S6 kinase alpha-3, 2,6-difluoro-4-{4-[4-(4-methylpiperazin-1-yl)phenyl]pyridin-3-yl}phenol (3 entities in total)
Functional Keywordskinase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological sourceHomo sapiens (human)
Cellular locationNucleus : P51812
Total number of polymer chains1
Total formula weight37586.41
Authors
Appleton, B.A. (deposition date: 2013-12-04, release date: 2014-03-05, Last modification date: 2024-02-28)
Primary citationAronchik, I.,Appleton, B.A.,Basham, S.E.,Crawford, K.,Del Rosario, M.,Doyle, L.V.,Estacio, W.F.,Lan, J.,Lindvall, M.K.,Luu, C.A.,Ornelas, E.,Venetsanakos, E.,Shafer, C.M.,Jefferson, A.B.
Novel potent and selective inhibitors of p90 ribosomal S6 kinase reveal the heterogeneity of RSK function in MAPK-driven cancers.
Mol Cancer Res, 12:803-812, 2014
Cited by
PubMed: 24554780
DOI: 10.1158/1541-7786.MCR-13-0595
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.39 Å)
Structure validation

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