4NTR

Crystal structure of macrocycles containing Abeta 17-23 (LVFFAED) and Abeta 30-36 (AII(SAR)L(ORN)V)

4NTR の概要

• エントリーDOI: 10.2210/pdb4ntr/pdb
• 関連するPDBエントリー: 4NTP 4NW8 4NW9
• 分子名称: Cyclic hexadecapeptide (ORN)LVFFAED(ORN)AII(SAR)L(ORN)V, CHLORIDE ION, SODIUM ION, ... (4 entities in total)
• 機能のキーワード: beta-sheet, beta-hairpin, amyloid, amyloid beta-sheet mimic, de novo protein-protein binding complex, de novo protein, protein binding
• 由来する生物種: synthetic construct
• タンパク質・核酸の鎖数: 16
• 化学式量合計: 28562.64

構造登録者

Spencer, R.K.,Li, H.,Nowick, J.S. (登録日: 2013-12-02, 公開日: 2014-04-02, 最終更新日: 2023-09-20)

主引用文献

Spencer, R.K.,Li, H.,Nowick, J.S.
X-ray crystallographic structures of trimers and higher-order oligomeric assemblies of a peptide derived from A beta (17-36).
J.Am.Chem.Soc., 136:5595-5598, 2014

PubMed Abstract: A peptide derived from Aβ17-36 crystallizes to form trimers that further associate to form higher-order oligomers. The trimers consist of three highly twisted β-hairpins in a triangular arrangement. Two trimers associate face-to-face in the crystal lattice to form a hexamer; four trimers in a tetrahedral arrangement about a central cavity form a dodecamer. These structures provide a working model for the structures of oligomers associated with neurodegeneration in Alzheimer's disease.

PubMed: 24669800
DOI: 10.1021/ja5017409

実験手法

X-RAY DIFFRACTION (1.7 Å)