4NTR

Crystal structure of macrocycles containing Abeta 17-23 (LVFFAED) and Abeta 30-36 (AII(SAR)L(ORN)V)

Summary for 4NTR

• Entry DOI: 10.2210/pdb4ntr/pdb
• Related: 4NTP 4NW8 4NW9
• Descriptor: Cyclic hexadecapeptide (ORN)LVFFAED(ORN)AII(SAR)L(ORN)V, CHLORIDE ION, SODIUM ION, ... (4 entities in total)
• Functional Keywords: beta-sheet, beta-hairpin, amyloid, amyloid beta-sheet mimic, de novo protein-protein binding complex, de novo protein, protein binding
• Biological source: synthetic construct
• Total number of polymer chains: 16
• Total formula weight: 28562.64

Authors

Spencer, R.K.,Li, H.,Nowick, J.S. (deposition date: 2013-12-02, release date: 2014-04-02, Last modification date: 2023-09-20)

• Primary citation: Spencer, R.K.,Li, H.,Nowick, J.S.; X-ray crystallographic structures of trimers and higher-order oligomeric assemblies of a peptide derived from A beta (17-36).; J.Am.Chem.Soc., 136:5595-5598, 2014; PubMed: 24669800; DOI: 10.1021/ja5017409

Experimental method

X-RAY DIFFRACTION (1.7 Å)