4NTP

Crystal structure of macrocycles containing A 17-23 (LV(PHI)FAED) and A 30-36 (AII(SAR)L(ORN)V)

Summary for 4NTP

• Entry DOI: 10.2210/pdb4ntp/pdb
• Related: 4NTR 4NW8 4NW9
• Descriptor: Cyclic hexadecapeptide (ORN)LV(PHI)FAED(ORN)AII(SAR)L(ORN)V, SODIUM ION, CHLORIDE ION, ... (4 entities in total)
• Functional Keywords: beta-sheet, beta-hairpin, amyloid, phe19 changed to p-iodo-phenylalanine, de novo protein, protein binding
• Biological source: synthetic construct
• Total number of polymer chains: 16
• Total formula weight: 30447.65

Authors

Nowick, J.S.,Spencer, R.K.,Li, H. (deposition date: 2013-12-02, release date: 2014-04-02, Last modification date: 2020-10-21)

• Primary citation: Spencer, R.K.,Li, H.,Nowick, J.S.; X-ray crystallographic structures of trimers and higher-order oligomeric assemblies of a peptide derived from A beta (17-36).; J.Am.Chem.Soc., 136:5595-5598, 2014; PubMed: 24669800; DOI: 10.1021/ja5017409

Experimental method

X-RAY DIFFRACTION (1.987 Å)