4NRC

Crystal Structure of the bromodomain of human BAZ2B in complex with compound-3 N01186

Summary for 4NRC

Entry DOI	10.2210/pdb4nrc/pdb
Related	4NR9 4NRA 4NRB
Descriptor	Bromodomain adjacent to zinc finger domain protein 2B, N-methyl-2,3-dihydrothieno[3,4-b][1,4]dioxine-5-carboxamide, 1,2-ETHANEDIOL, ... (5 entities in total)
Functional Keywords	sgc, structural genomics consortium, transcription, bromodomain, acetylated lysine binding protein, kiaa1476, walp4
Biological source	Homo sapiens (human)
Cellular location	Nucleus (Potential): Q9UIF8
Total number of polymer chains	1
Total formula weight	15471.84
Authors	Muniz, J.R.C.,Felletar, I.,Chaikuad, A.,Filippakopoulos, P.,Ferguson, F.M.,Fedorov, O.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Ciulli, A.,Knapp, S.,Structural Genomics Consortium (SGC) (deposition date: 2013-11-26, release date: 2013-12-25, Last modification date: 2023-09-20)
Primary citation	Ferguson, F.M.,Fedorov, O.,Chaikuad, A.,Philpott, M.,Muniz, J.R.,Felletar, I.,von Delft, F.,Heightman, T.,Knapp, S.,Abell, C.,Ciulli, A. Targeting low-druggability bromodomains: fragment based screening and inhibitor design against the BAZ2B bromodomain. J.Med.Chem., 56:10183-10187, 2013 Cited by PubMed: 24304323 DOI: 10.1021/jm401582c PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.86 Å)

Structure validation