4NQ1
Legionella pneumophila dihydrodipicolinate synthase with first substrate pyruvate bound in the active site
Summary for 4NQ1
Entry DOI | 10.2210/pdb4nq1/pdb |
Descriptor | 4-hydroxy-tetrahydrodipicolinate synthase, (4R)-2-METHYLPENTANE-2,4-DIOL, CHLORIDE ION, ... (6 entities in total) |
Functional Keywords | tim barrel, lysine biosynthesis, dihydrodipicolinate synthesis, pyruvate, lyase |
Biological source | Legionella pneumophila |
Cellular location | Cytoplasm (By similarity): D5T7I7 |
Total number of polymer chains | 2 |
Total formula weight | 63944.66 |
Authors | Siddiqui, T.,Paxman, J.J. (deposition date: 2013-11-23, release date: 2014-01-01, Last modification date: 2023-11-29) |
Primary citation | Siddiqui, T.,Paxman, J.J.,Dogovski, C.,Panjikar, S.,Perugini, M.A. Legionella pneumophila DHDPS: The First Case of Non-Lysine Inhibition in a Gram-Negative Pathogen To be Published, |
Experimental method | X-RAY DIFFRACTION (1.65 Å) |
Structure validation
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