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4NN7

Cytokine receptor complex - Crystal form 2

4NN7 の概要
エントリーDOI10.2210/pdb4nn7/pdb
関連するPDBエントリー4NN5 4NN6
分子名称Thymic stromal lymphopoietin, Interleukin-7 receptor subunit alpha, Cytokine receptor-like factor 2 (3 entities in total)
機能のキーワードfour helical bundle fold, chr domains, tslp cytokine signaling, tslpr and il-7ralpha receptors, cell surface, cytokine-cytokine receptor complex, cytokine/cytokine receptor
由来する生物種Mus musculus (mouse)
詳細
細胞内の位置Secreted : Q9JIE6
Membrane; Single-pass type I membrane protein: P16872
Isoform 1: Cell membrane; Single-pass type I membrane protein. Isoform 3: Cell membrane; Single-pass type I membrane protein. Isoform 2: Secreted: Q8CII9
タンパク質・核酸の鎖数3
化学式量合計63354.11
構造登録者
Verstraete, K.,van Schie, L.,Savvides, S.N. (登録日: 2013-11-16, 公開日: 2014-03-19, 最終更新日: 2023-09-20)
主引用文献Verstraete, K.,van Schie, L.,Vyncke, L.,Bloch, Y.,Tavernier, J.,Pauwels, E.,Peelman, F.,Savvides, S.N.
Structural basis of the proinflammatory signaling complex mediated by TSLP.
Nat.Struct.Mol.Biol., 21:375-382, 2014
Cited by
PubMed Abstract: Thymic stromal lymphopoietin (TSLP), a cytokine produced by epithelial cells at barrier surfaces, is pivotal for the development of widespread chronic inflammatory disorders such as asthma and atopic dermatitis. The structure of the mouse TSLP-mediated signaling complex reveals how TSLP establishes extensive interfaces with its cognate receptor (TSLPR) and the shared interleukin 7 receptor α-chain (IL-7Rα) to evoke membrane-proximal receptor-receptor contacts poised for intracellular signaling. Binding of TSLP to TSLPR is a mechanistic prerequisite for recruitment of IL-7Rα to the high-affinity ternary complex, which we propose is coupled to a structural switch in TSLP at the crossroads of the cytokine-receptor interfaces. Functional interrogation of TSLP-receptor interfaces points to putative interaction hotspots that could be exploited for antagonist design. Finally, we derive the structural rationale for the functional duality of IL-7Rα and establish a consensus for the geometry of ternary complexes mediated by interleukin 2 (IL-2)-family cytokines.
PubMed: 24632570
DOI: 10.1038/nsmb.2794
主引用文献が同じPDBエントリー
実験手法
X-RAY DIFFRACTION (3.775 Å)
構造検証レポート
Validation report summary of 4nn7
検証レポート(詳細版)ダウンロードをダウンロード

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件を2024-10-30に公開中

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