4NN7
Cytokine receptor complex - Crystal form 2
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0001961 | biological_process | positive regulation of cytokine-mediated signaling pathway |
| A | 0005125 | molecular_function | cytokine activity |
| A | 0005139 | molecular_function | interleukin-7 receptor binding |
| A | 0005515 | molecular_function | protein binding |
| A | 0005576 | cellular_component | extracellular region |
| A | 0005615 | cellular_component | extracellular space |
| A | 0007165 | biological_process | signal transduction |
| A | 0032722 | biological_process | positive regulation of chemokine production |
| A | 0032733 | biological_process | positive regulation of interleukin-10 production |
| A | 0032736 | biological_process | positive regulation of interleukin-13 production |
| A | 0032754 | biological_process | positive regulation of interleukin-5 production |
| A | 0032755 | biological_process | positive regulation of interleukin-6 production |
| A | 0050729 | biological_process | positive regulation of inflammatory response |
| B | 0004896 | molecular_function | cytokine receptor activity |
| B | 0016020 | cellular_component | membrane |
Functional Information from PROSITE/UniProt
| site_id | PS01355 |
| Number of Residues | 33 |
| Details | HEMATOPO_REC_S_F1 Short hematopoietin receptor family 1 signature. LrpkamyeikVRsiphndyfkgf.........WSeWSpsstF |
| Chain | Residue | Details |
| B | LEU195-PHE227 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | Site: {"description":"Inserts into a conserved IL7R hydrophobic pocket, important for IL7R-binding","evidences":[{"source":"PubMed","id":"24632570","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 7 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 101 |
| Details | Domain: {"description":"Fibronectin type-III","evidences":[{"source":"PROSITE-ProRule","id":"PRU00316","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 8 |
| Details | Motif: {"description":"WSXWS motif"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"24632570","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
