4NLS

Poliovirus Polymerase - S288A Loop Mutant

Summary for 4NLS

• Entry DOI: 10.2210/pdb4nls/pdb
• Related: 4NLO 4NLP 4NLQ 4NLR 4NLT 4NLU 4NLV 4NLW 4NLX 4NLY
• Descriptor: RNA-directed RNA polymerase 3D-POL, ACETIC ACID, PENTAETHYLENE GLYCOL, ... (5 entities in total)
• Functional Keywords: polymerase, rna dependent rna polymerase, rdrp, virus, viral protein, hydrolase
• Biological source: Human poliovirus 1
• Cellular location: Capsid protein VP0: Virion. Capsid protein VP4: Virion. Capsid protein VP2: Virion. Capsid protein VP3: Virion. Capsid protein VP1: Virion. Protein 2B: Host cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side (Potential). Protein 2C: Host cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side (Potential). Protein 3A: Host cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side (Potential). Protein 3AB: Host cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side (Potential). Viral protein genome-linked: Virion. Protease 3C: Host cytoplasm. Protein 3CD: Host cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side (Potential). RNA-directed RNA polymerase: Host cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side (Potential): P03300
• Total number of polymer chains: 1
• Total formula weight: 54009.94

Authors

Sholders, A.J.,Peersen, O.B. (deposition date: 2013-11-14, release date: 2014-01-22, Last modification date: 2023-09-20)

• Primary citation: Sholders, A.J.,Peersen, O.B.; Distinct conformations of a putative translocation element in poliovirus polymerase.; J.Mol.Biol., 426:1407-1419, 2014; PubMed: 24424421; DOI: 10.1016/j.jmb.2013.12.031

Experimental method

X-RAY DIFFRACTION (2 Å)