4NKY
Human steroidogenic cytochrome P450 17A1 mutant A105L with substrate 17alpha-hydroxyprogesterone
Summary for 4NKY
Entry DOI | 10.2210/pdb4nky/pdb |
Related | 3RUK 3SWZ 4NKV 4NKW 4NKX 4NKZ |
Descriptor | Steroid 17-alpha-hydroxylase/17,20 lyase, PROTOPORPHYRIN IX CONTAINING FE, (9beta)-17-hydroxypregn-4-ene-3,20-dione, ... (4 entities in total) |
Functional Keywords | heme protein, monooxygenase, steroid 17alpha-hydroxylase, steroid c17, 20 lyase, nadph-cytochrome p450 reductase, cytochrome b5, endoplasmic reticulum membrane, oxidoreductase, lyase |
Biological source | Homo sapiens (human) |
Cellular location | Membrane : P05093 |
Total number of polymer chains | 4 |
Total formula weight | 226916.68 |
Authors | Scott, E.E.,Petrunak, E.M. (deposition date: 2013-11-13, release date: 2014-10-22, Last modification date: 2023-09-20) |
Primary citation | Petrunak, E.M.,DeVore, N.M.,Porubsky, P.R.,Scott, E.E. Structures of Human Steroidogenic Cytochrome P450 17A1 with Substrates. J.Biol.Chem., 289:32952-32964, 2014 Cited by PubMed: 25301938DOI: 10.1074/jbc.M114.610998 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.55 Å) |
Structure validation
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