3SWZ

Human Cytochrome P450 17A1 in complex with TOK-001

Summary for 3SWZ

Entry DOI	10.2210/pdb3swz/pdb
Related	3RUK
Descriptor	Steroid 17-alpha-hydroxylase/17,20 lyase, PROTOPORPHYRIN IX CONTAINING FE, (3alpha,8alpha)-17-(1H-benzimidazol-1-yl)androsta-5,16-dien-3-ol, ... (4 entities in total)
Functional Keywords	cytochrome p450, p450, cyp17a1, p450c17, p450 17a1, monooxygenase, 17a-hydroxylase, 17, 20-lyase, heme protein, cytochrome p450 oxidoreductase, galeterone, membrane, tok-001, vn/124-1, microsome, endoplasmic reticulum, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor
Biological source	Homo sapiens (human)
Cellular location	Membrane : P05093
Total number of polymer chains	4
Total formula weight	226980.69
Authors	DeVore, N.M.,Scott, E.E. (deposition date: 2011-07-14, release date: 2012-01-25, Last modification date: 2023-09-13)
Primary citation	Devore, N.M.,Scott, E.E. Structures of cytochrome P450 17A1 with prostate cancer drugs abiraterone and TOK-001. Nature, 482:116-119, 2012 Cited by PubMed: 22266943 DOI: 10.1038/nature10743 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.4 Å)

Structure validation