4NKW

Human steroidogenic cytochrome P450 17A1 mutant A105L with substrate pregnenolone

Summary for 4NKW

Entry DOI	10.2210/pdb4nkw/pdb
Related	3RUK 3SWZ 4NKV 4NKX 4NKY 4NKZ
Descriptor	Steroid 17-alpha-hydroxylase/17,20 lyase, PROTOPORPHYRIN IX CONTAINING FE, (3BETA)-3-HYDROXYPREGN-5-EN-20-ONE, ... (4 entities in total)
Functional Keywords	heme protein, monooxygenase, steroid 17alpha-hydroxylase, steroid c17, 20 lyase, nadph-cytochrome p450 reductase, cytochrome b5, endoplasmic reticulum membrane, oxidoreductase, lyase
Biological source	Homo sapiens (human)
Cellular location	Membrane : P05093
Total number of polymer chains	4
Total formula weight	226860.75
Authors	Scott, E.E.,Petrunak, E.P. (deposition date: 2013-11-13, release date: 2014-10-22, Last modification date: 2023-09-20)
Primary citation	Petrunak, E.M.,DeVore, N.M.,Porubsky, P.R.,Scott, E.E. Structures of Human Steroidogenic Cytochrome P450 17A1 with Substrates. J.Biol.Chem., 289:32952-32964, 2014 Cited by PubMed: 25301938 DOI: 10.1074/jbc.M114.610998 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.5 Å)

Structure validation