4NJ4
Crystal Structure of Human ALKBH5
Summary for 4NJ4
Entry DOI | 10.2210/pdb4nj4/pdb |
Descriptor | RNA demethylase ALKBH5, MANGANESE (II) ION, NITRATE ION, ... (6 entities in total) |
Functional Keywords | double-stranded beta helix, jelly-roll motif, dioxygenase, rna demethylase, rna, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Nucleus speckle: Q6P6C2 |
Total number of polymer chains | 2 |
Total formula weight | 58630.85 |
Authors | Aik, W.S.,McDonough, M.A.,Schofield, C.J. (deposition date: 2013-11-08, release date: 2014-01-15, Last modification date: 2023-09-20) |
Primary citation | Aik, W.,Scotti, J.S.,Choi, H.,Gong, L.,Demetriades, M.,Schofield, C.J.,McDonough, M.A. Structure of human RNA N6-methyladenine demethylase ALKBH5 provides insights into its mechanisms of nucleic acid recognition and demethylation. Nucleic Acids Res., 42:4741-4754, 2014 Cited by PubMed: 24489119DOI: 10.1093/nar/gku085 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.02 Å) |
Structure validation
Download full validation report