4NJ4

Crystal Structure of Human ALKBH5

4NJ4 の概要

• エントリーDOI: 10.2210/pdb4nj4/pdb
• 分子名称: RNA demethylase ALKBH5, MANGANESE (II) ION, NITRATE ION, ... (6 entities in total)
• 機能のキーワード: double-stranded beta helix, jelly-roll motif, dioxygenase, rna demethylase, rna, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Nucleus speckle: Q6P6C2
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 58630.85

構造登録者

Aik, W.S.,McDonough, M.A.,Schofield, C.J. (登録日: 2013-11-08, 公開日: 2014-01-15, 最終更新日: 2023-09-20)

• 主引用文献: Aik, W.,Scotti, J.S.,Choi, H.,Gong, L.,Demetriades, M.,Schofield, C.J.,McDonough, M.A.; Structure of human RNA N6-methyladenine demethylase ALKBH5 provides insights into its mechanisms of nucleic acid recognition and demethylation.; Nucleic Acids Res., 42:4741-4754, 2014; PubMed: 24489119; DOI: 10.1093/nar/gku085

実験手法

X-RAY DIFFRACTION (2.02 Å)