4NEE
crystal structure of AP-2 alpha/simga2 complex bound to HIV-1 Nef
Summary for 4NEE
Entry DOI | 10.2210/pdb4nee/pdb |
Descriptor | AP-2 complex subunit sigma, AP-2 complex subunit alpha-2, Protein Nef (3 entities in total) |
Functional Keywords | clathrin adaptor ap-2, hiv-1 nef, cd4 downregulation, viral protein-protein transport complex, viral protein/protein transport |
Biological source | Rattus norvegicus (brown rat,rat,rats) More |
Cellular location | Cell membrane: Q66HM2 |
Total number of polymer chains | 12 |
Total formula weight | 316395.85 |
Authors | Hurley, J.H.,Bonifacino, J.S.,Ren, X.,Park, S.Y. (deposition date: 2013-10-29, release date: 2014-01-29, Last modification date: 2023-09-20) |
Primary citation | Ren, X.,Park, S.Y.,Bonifacino, J.S.,Hurley, J.H. How HIV-1 Nef hijacks the AP-2 clathrin adaptor to downregulate CD4. Elife, 3:e01754-e01754, 2014 Cited by PubMed: 24473078DOI: 10.7554/eLife.01754 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.8841 Å) |
Structure validation
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