4NC5
Human sialidase 2 in complex with 2,3-difluorosialic acid (covalent intermediate)
Summary for 4NC5
Entry DOI | 10.2210/pdb4nc5/pdb |
Related | 2A75 2AH2 |
Descriptor | Sialidase-2, 5-acetamido-3,5-dideoxy-3-fluoro-D-erythro-alpha-L-manno-non-2-ulopyranosonic acid, PHOSPHATE ION, ... (4 entities in total) |
Functional Keywords | human neuraminidase, sialidase, hydrolase |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 1 |
Total formula weight | 42892.79 |
Authors | Buchini, S.,Gallat, F.-X.,Greig, I.R.,Kim, J.-H.,Wakatsuki, S.,Chavas, L.M.G.,Withers, S.G. (deposition date: 2013-10-24, release date: 2013-11-06, Last modification date: 2023-09-20) |
Primary citation | Buchini, S.,Gallat, F.X.,Greig, I.R.,Kim, J.H.,Wakatsuki, S.,Chavas, L.M.,Withers, S.G. Tuning mechanism-based inactivators of neuraminidases: mechanistic and structural insights. Angew.Chem.Int.Ed.Engl., 53:3382-3386, 2014 Cited by PubMed: 24591206DOI: 10.1002/anie.201309675 PDB entries with the same primary citation |
Experimental method |
Structure validation
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