4NC5
Human sialidase 2 in complex with 2,3-difluorosialic acid (covalent intermediate)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Sialidase-2 | polymer | 382 | 42375.6 | 1 | UniProt (Q9Y3R4) Pfam (PF13088) | Homo sapiens (human) | NEU2, Cytosolic sialidase, N-acetyl-alpha-neuraminidase 2 |
| 2 | B (A) | 5-acetamido-3,5-dideoxy-3-fluoro-D-erythro-alpha-L-manno-non-2-ulopyranosonic acid | non-polymer | 327.3 | 1 | Chemie (FSI) | |||
| 3 | C, D (A) | PHOSPHATE ION | non-polymer | 95.0 | 2 | Chemie (PO4) | |||
| 4 | E (A) | water | water | 18.0 | 103 | Chemie (HOH) |
Sequence modifications
A: 1 - 380 (UniProt: Q9Y3R4)
| PDB | External Database | Details |
|---|---|---|
| Gly -1 | - | expression tag |
| Ser 0 | - | expression tag |
| Ala 46 | Asp 46 | engineered mutation |
| Asn 168 | His 168 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 42375.6 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 517.2 | |
| All* | Total formula weight | 42892.8 |
