4NC5
Human sialidase 2 in complex with 2,3-difluorosialic acid (covalent intermediate)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Sialidase-2 | polymer | 382 | 42375.6 | 1 | UniProt (Q9Y3R4) Pfam (PF13088) | Homo sapiens (human) | NEU2, Cytosolic sialidase, N-acetyl-alpha-neuraminidase 2 |
| 2 | B (A) | 5-acetamido-3,5-dideoxy-3-fluoro-D-erythro-alpha-L-manno-non-2-ulopyranosonic acid | non-polymer | 327.3 | 1 | Chemie (FSI) PubChem (23628524) PubChem (23628525) PubChem (150864) PubChem (448471) PubChem (58753593) PubChem (71065668) PubChem (72206646) PubChem (91532921) PubChem (9949281) PubChem (11450242) PubChem (14101566) PubChem (118479993) PubChem (129678999) PubChem (129715278) PubChem (134972939) PubChem (135016585) PubChem (155168392) PubChem (168356717) PubChem (168373736) | |||
| 3 | C, D (A) | PHOSPHATE ION | non-polymer | 95.0 | 2 | Chemie (PO4) PubChem (1061) | |||
| 4 | E (A) | water | water | 18.0 | 103 | Chemie (HOH) |
Sequence modifications
A: 1 - 380 (UniProt: Q9Y3R4)
| PDB | External Database | Details |
|---|---|---|
| Gly -1 | - | expression tag |
| Ser 0 | - | expression tag |
| Ala 46 | Asp 46 | engineered mutation |
| Asn 168 | His 168 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 42375.6 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 517.2 | |
| All* | Total formula weight | 42892.8 |
