4NAK

Arabidopsis thaliana IspD in complex with pentabromo-pseudilin

Summary for 4NAK

Entry DOI	10.2210/pdb4nak/pdb
Related	1INI 1W77 2YC5 4NAI 4NAL 4NAN
Descriptor	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase, chloroplastic, PENTABROMOPSEUDILIN, 2,3-DIHYDROXY-1,4-DITHIOBUTANE, ... (6 entities in total)
Functional Keywords	herbicide, anti-infectives, pseudilin, natural product, drug discovery, allosteric inhibition, rossmann fold, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Arabidopsis thaliana (mouse-ear cress, thale-cress)
Cellular location	Plastid, chloroplast stroma (Probable): P69834
Total number of polymer chains	1
Total formula weight	26934.75
Authors	Kunfermann, A.,Witschel, M.,Illarionov, B.,Martin, R.,Rottmann, M.,Hoffken, H.W.,Seet, M.,Eisenreich, W.,Knolker, H.-J.,Fischer, M.,Bacher, A.,Groll, M.,Diederich, F. (deposition date: 2013-10-22, release date: 2014-01-29, Last modification date: 2023-09-20)
Primary citation	Kunfermann, A.,Witschel, M.,Illarionov, B.,Martin, R.,Rottmann, M.,Hoffken, H.W.,Seet, M.,Eisenreich, W.,Knolker, H.J.,Fischer, M.,Bacher, A.,Groll, M.,Diederich, F. Pseudilins: Halogenated, Allosteric Inhibitors of the Non-Mevalonate Pathway Enzyme IspD. Angew.Chem.Int.Ed.Engl., 53:2235-2239, 2014 Cited by PubMed: 24446431 DOI: 10.1002/anie.201309557 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.8 Å)

Structure validation