4N9F
Crystal structure of the Vif-CBFbeta-CUL5-ElOB-ElOC pentameric complex
Summary for 4N9F
Entry DOI | 10.2210/pdb4n9f/pdb |
Descriptor | Cullin-5, Transcription elongation factor B polypeptide 1, Transcription elongation factor B polypeptide 2, ... (6 entities in total) |
Functional Keywords | zinc finger motif, stabilize vif interaction with cul5, cul5, transcription-viral protein complex, ligase-viral protein complex, ligase/viral protein |
Biological source | Homo sapiens (human) More |
Cellular location | Nucleus (Probable): Q15369 Q15370 Nucleus (Potential): Q13951 Host cytoplasm: Q72499 |
Total number of polymer chains | 60 |
Total formula weight | 1200461.93 |
Authors | Guo, Y.Y.,Dong, L.Y.,Huang, Z.W. (deposition date: 2013-10-21, release date: 2014-01-08, Last modification date: 2023-11-08) |
Primary citation | Guo, Y.Y.,Dong, L.Y.,Qiu, X.L.,Wang, Y.S.,Zhang, B.L.,Liu, H.N.,Yu, Y.,Zang, Y.,Yang, M.J.,Huang, Z.W. Structural basis for hijacking CBF-b and CUL5 E3 ligase complex by HIV-1 Vif Nature, 505:229-233, 2014 |
Experimental method | X-RAY DIFFRACTION (3.3 Å) |
Structure validation
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