4N5V

Alternative substrates of Mycobacterium tuberculosis anthranilate phosphoribosyl transferase

4N5V の概要

• エントリーDOI: 10.2210/pdb4n5v/pdb
• 関連するPDBエントリー: 2BPQ 3QR9 4N8Q 4N93
• 分子名称: Anthranilate phosphoribosyltransferase, 1-O-pyrophosphono-5-O-phosphono-alpha-D-ribofuranose, MAGNESIUM ION, ... (6 entities in total)
• 機能のキーワード: anthranilate phosphoribosyltransferase, anthranilic acids, magnesium, tryptophan, inhibitor, transferase, magnesium binding phosphoribosyl pyrophosphate
• 由来する生物種: Mycobacterium tuberculosis
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 79355.84

構造登録者

Castell, A.,Cookson, T.V.M.,Parker, E.J.,Baker, E.N.,Lott, J.S. (登録日: 2013-10-10, 公開日: 2014-04-23, 最終更新日: 2023-09-20)

• 主引用文献: Cookson, T.V.,Castell, A.,Bulloch, E.M.,Evans, G.L.,Short, F.L.,Baker, E.N.,Lott, J.S.,Parker, E.J.; Alternative substrates reveal catalytic cycle and key binding events in the reaction catalysed by anthranilate phosphoribosyltransferase from Mycobacterium tuberculosis.; Biochem.J., 461:87-98, 2014; PubMed: 24712732; DOI: 10.1042/BJ20140209

実験手法

X-RAY DIFFRACTION (1.9 Å)