4N5T
The 1.7A Crystal Structure of MDMX with a Stapled Peptide, ATSP-7041
Summary for 4N5T
Entry DOI | 10.2210/pdb4n5t/pdb |
Related PRD ID | PRD_001189 |
Descriptor | Protein Mdm4, ATSP-7041 stapled-peptide (3 entities in total) |
Functional Keywords | mdm4, p53, apoptosis, cell cycle, p53 antagonist, nucleus, cell cycle-cell cycle inhibitor complex, cell cycle/cell cycle inhibitor |
Biological source | Danio rerio (leopard danio, zebra danio, zebra fish) More |
Cellular location | Nucleus : Q7ZUW7 |
Total number of polymer chains | 2 |
Total formula weight | 12056.12 |
Authors | Graves, B.J.,Lukacs, C.,Janson, C.A. (deposition date: 2013-10-10, release date: 2013-11-20, Last modification date: 2023-11-15) |
Primary citation | Chang, Y.S.,Graves, B.,Guerlavais, V.,Tovar, C.,Packman, K.,To, K.H.,Olson, K.A.,Kesavan, K.,Gangurde, P.,Mukherjee, A.,Baker, T.,Darlak, K.,Elkin, C.,Filipovic, Z.,Qureshi, F.Z.,Cai, H.,Berry, P.,Feyfant, E.,Shi, X.E.,Horstick, J.,Annis, D.A.,Manning, A.M.,Fotouhi, N.,Nash, H.,Vassilev, L.T.,Sawyer, T.K. Stapled alpha-helical peptide drug development: a potent dual inhibitor of MDM2 and MDMX for p53-dependent cancer therapy. Proc.Natl.Acad.Sci.USA, 110:E3445-E3454, 2013 Cited by PubMed: 23946421DOI: 10.1073/pnas.1303002110 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.7 Å) |
Structure validation
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