4N5T

The 1.7A Crystal Structure of MDMX with a Stapled Peptide, ATSP-7041

4N5T の概要

• エントリーDOI: 10.2210/pdb4n5t/pdb
• 関連するBIRD辞書のPRD_ID: PRD_001189
• 分子名称: Protein Mdm4, ATSP-7041 stapled-peptide (3 entities in total)
• 機能のキーワード: mdm4, p53, apoptosis, cell cycle, p53 antagonist, nucleus, cell cycle-cell cycle inhibitor complex, cell cycle/cell cycle inhibitor
• 由来する生物種: Danio rerio (leopard danio, zebra danio, zebra fish); 詳細
• 細胞内の位置: Nucleus : Q7ZUW7
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 12056.12

構造登録者

Graves, B.J.,Lukacs, C.,Janson, C.A. (登録日: 2013-10-10, 公開日: 2013-11-20, 最終更新日: 2023-11-15)

• 主引用文献: Chang, Y.S.,Graves, B.,Guerlavais, V.,Tovar, C.,Packman, K.,To, K.H.,Olson, K.A.,Kesavan, K.,Gangurde, P.,Mukherjee, A.,Baker, T.,Darlak, K.,Elkin, C.,Filipovic, Z.,Qureshi, F.Z.,Cai, H.,Berry, P.,Feyfant, E.,Shi, X.E.,Horstick, J.,Annis, D.A.,Manning, A.M.,Fotouhi, N.,Nash, H.,Vassilev, L.T.,Sawyer, T.K.; Stapled alpha-helical peptide drug development: a potent dual inhibitor of MDM2 and MDMX for p53-dependent cancer therapy.; Proc.Natl.Acad.Sci.USA, 110:E3445-E3454, 2013; PubMed: 23946421; DOI: 10.1073/pnas.1303002110

実験手法

X-RAY DIFFRACTION (1.7 Å)